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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
AGL
All Species:
21.52
Human Site:
Y677
Identified Species:
43.03
UniProt:
P35573
Number Species:
11
Phosphosite Substitution
Charge Score:
-0.18
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P35573
NP_000019.2
1532
174764
Y677
V
V
S
E
E
R
F
Y
T
K
W
N
P
E
A
Chimpanzee
Pan troglodytes
XP_524777
1532
174746
Y677
V
V
S
E
E
R
F
Y
T
K
W
N
P
E
A
Rhesus Macaque
Macaca mulatta
XP_001106231
1532
174684
Y677
V
V
S
E
E
R
F
Y
T
K
W
N
P
E
A
Dog
Lupus familis
Cat
Felis silvestris
Mouse
Mus musculus
NP_001074795
1532
174269
Y677
V
V
A
E
E
R
F
Y
T
K
W
N
P
G
A
Rat
Rattus norvegicus
NP_001102034
1532
174314
Y677
V
V
A
E
E
R
F
Y
T
K
W
N
P
G
A
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001512323
1163
131293
R365
E
D
I
V
A
V
T
R
H
C
P
S
S
H
Q
Chicken
Gallus gallus
XP_422317
1532
174660
F677
S
V
V
S
E
E
R
F
Y
S
T
W
N
P
Q
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
XP_696194
1052
117860
R254
E
D
I
V
A
V
T
R
H
C
P
S
T
H
Q
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_726062
1629
183200
Y798
V
V
D
E
E
R
T
Y
Q
E
W
G
K
G
V
Honey Bee
Apis mellifera
XP_394961
1549
176545
S680
V
D
E
T
R
Q
Y
S
F
W
T
D
D
E
C
Nematode Worm
Caenorhab. elegans
NP_496984
1467
165910
V662
I
R
D
H
I
H
V
V
S
E
K
R
P
Y
A
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Q06625
1536
174953
V680
T
P
F
E
K
R
T
V
E
D
T
L
P
N
A
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.8
97.6
N.A.
N.A.
91.9
92.1
N.A.
67.6
81.7
N.A.
53.3
N.A.
45.2
49.9
44.2
N.A.
Protein Similarity:
100
100
99.2
N.A.
N.A.
96.6
96.4
N.A.
72
91.5
N.A.
61.3
N.A.
61.4
66.6
62
N.A.
P-Site Identity:
100
100
100
N.A.
N.A.
86.6
86.6
N.A.
0
13.3
N.A.
0
N.A.
46.6
13.3
13.3
N.A.
P-Site Similarity:
100
100
100
N.A.
N.A.
93.3
93.3
N.A.
6.6
20
N.A.
6.6
N.A.
53.3
33.3
33.3
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
35.8
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
52.9
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
26.6
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
33.3
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
17
0
17
0
0
0
0
0
0
0
0
0
59
% A
% Cys:
0
0
0
0
0
0
0
0
0
17
0
0
0
0
9
% C
% Asp:
0
25
17
0
0
0
0
0
0
9
0
9
9
0
0
% D
% Glu:
17
0
9
59
59
9
0
0
9
17
0
0
0
34
0
% E
% Phe:
0
0
9
0
0
0
42
9
9
0
0
0
0
0
0
% F
% Gly:
0
0
0
0
0
0
0
0
0
0
0
9
0
25
0
% G
% His:
0
0
0
9
0
9
0
0
17
0
0
0
0
17
0
% H
% Ile:
9
0
17
0
9
0
0
0
0
0
0
0
0
0
0
% I
% Lys:
0
0
0
0
9
0
0
0
0
42
9
0
9
0
0
% K
% Leu:
0
0
0
0
0
0
0
0
0
0
0
9
0
0
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
0
0
0
0
0
0
0
42
9
9
0
% N
% Pro:
0
9
0
0
0
0
0
0
0
0
17
0
59
9
0
% P
% Gln:
0
0
0
0
0
9
0
0
9
0
0
0
0
0
25
% Q
% Arg:
0
9
0
0
9
59
9
17
0
0
0
9
0
0
0
% R
% Ser:
9
0
25
9
0
0
0
9
9
9
0
17
9
0
0
% S
% Thr:
9
0
0
9
0
0
34
0
42
0
25
0
9
0
0
% T
% Val:
59
59
9
17
0
17
9
17
0
0
0
0
0
0
9
% V
% Trp:
0
0
0
0
0
0
0
0
0
9
50
9
0
0
0
% W
% Tyr:
0
0
0
0
0
0
9
50
9
0
0
0
0
9
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _